Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.drudis.2008.05.004
Title: Increasing the reliability of protein interactomes
Authors: Chua, H.N.
Wong, L. 
Issue Date: 2008
Source: Chua, H.N., Wong, L. (2008). Increasing the reliability of protein interactomes. Drug Discovery Today 13 (15-16) : 652-658. ScholarBank@NUS Repository. https://doi.org/10.1016/j.drudis.2008.05.004
Abstract: Protein interactions are crucial components of all cellular processes. An in-depth knowledge of the full complement of protein interactions in a cell, therefore, provides insight into the structure, properties and functions of the cell and its components. An accurate and comprehensive protein interaction network is, thus, an invaluable framework to study protein regulation in disease. Although the amount of protein-protein interaction data has grown significantly because of advances in high-throughput experimental techniques, these high-throughput methods are highly susceptible to noise. Therefore, computational techniques for assessing the reliability of a protein-protein interaction are highly desirable. We review here computational techniques for assessing and improving the reliability of protein-protein interaction data from these high-throughput experiments. © 2008 Elsevier Ltd. All rights reserved.
Source Title: Drug Discovery Today
URI: http://scholarbank.nus.edu.sg/handle/10635/42338
ISSN: 13596446
DOI: 10.1016/j.drudis.2008.05.004
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