Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.drudis.2007.07.014
Title: Rapid retrieval of protein structures from databases
Authors: Aung, Z.
Tan, K.-L. 
Issue Date: 2007
Source: Aung, Z.,Tan, K.-L. (2007). Rapid retrieval of protein structures from databases. Drug Discovery Today 12 (17-18) : 732-739. ScholarBank@NUS Repository. https://doi.org/10.1016/j.drudis.2007.07.014
Abstract: As protein databases continue to grow in size, exhaustive search methods that compare a query structure against every database structure can no longer provide satisfactory performance. Instead, the filter-and-refine paradigm offers an efficient alternative to database search without compromising the accuracy of the answers. In this paradigm, protein structures are represented in an abstract form. During querying, based on the abstract representations, the filtering phase prunes away dissimilar structures quickly so that only a small collection of promising structures are examined using a detailed structure alignment technique in the refinement phase. This article reviews mainly techniques developed for the filtering phase. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Drug Discovery Today
URI: http://scholarbank.nus.edu.sg/handle/10635/42327
ISSN: 13596446
DOI: 10.1016/j.drudis.2007.07.014
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