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|Title:||Automatic protein structure classification through structural fingerprinting|
|Citation:||Aung, Z.,Tan, K.-L. (2004). Automatic protein structure classification through structural fingerprinting. Proceedings - Fourth IEEE Symposium on Bioinformatics and Bioengineering, BIBE 2004 : 508-515. ScholarBank@NUS Repository.|
|Abstract:||In this paper, we present a new scheme named "CP-Mine" for automatic three-dimensional (3D) protein structure classification using structural fingerprints. We represent a 3D protein structure as a CPset, which is a set of inter-SSE contact patterns (CPs) existing in the protein. Suppose we have a database of protein structures whose class labels are already known, and suppose there are n distinct protein structure classes in the database. For each class, we generate its fingerprint by mining the frequent CPsets from all the member protein structures belonging to this class. When we want to predict the class label of an unknown protein, we also generate the CPset of this protein, and find the intersection between this CPset and the fingerprint of each protein structure class one by one. Then, the labels of the classes with the highest degree of intersection are returned as the answer. The proposed method is a pure classification scheme in that any kind of structural comparison, alignment or searching is not needed to be performed. The preliminary experimental results shows that our method can classify the protein structures accurately and efficiently.|
|Source Title:||Proceedings - Fourth IEEE Symposium on Bioinformatics and Bioengineering, BIBE 2004|
|Appears in Collections:||Staff Publications|
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