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Title: Protein interactome analysis for countering pathogen drug resistance
Authors: Wong, L. 
Liu, G. 
Keywords: Drug resistance
Infectious diseases
Protein complexes
Protein interactomes
Issue Date: 2009
Citation: Wong, L.,Liu, G. (2009). Protein interactome analysis for countering pathogen drug resistance. Journal of Computer Science and Technology 25 (1) : 124-130. ScholarBank@NUS Repository.
Abstract: Drug-resistant varieties of pathogens are now a recognized global threat. Insights into the routes for drug resistance in these pathogens are critical for developing more effective antibacterial drugs. A systems-level analysis of the genes, proteins, and interactions involved is an important step to gaining such insights. This paper discusses some of the computational challenges that must be surmounted to enable such an analysis; viz., unreliability of bacterial interactome maps, paucity of bacterial interactome maps, and identification of pathways to bacterial drug resistance. © 2010 Springer.
Source Title: Journal of Computer Science and Technology
ISSN: 10009000
DOI: 10.1007/s11390-010-9310-8
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