Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.cell.2011.12.014
DC Field | Value | |
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dc.title | Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation | |
dc.contributor.author | Li, G. | |
dc.contributor.author | Ruan, X. | |
dc.contributor.author | Auerbach, R.K. | |
dc.contributor.author | Sandhu, K.S. | |
dc.contributor.author | Zheng, M. | |
dc.contributor.author | Wang, P. | |
dc.contributor.author | Poh, H.M. | |
dc.contributor.author | Goh, Y. | |
dc.contributor.author | Lim, J. | |
dc.contributor.author | Zhang, J. | |
dc.contributor.author | Sim, H.S. | |
dc.contributor.author | Peh, S.Q. | |
dc.contributor.author | Mulawadi, F.H. | |
dc.contributor.author | Ong, C.T. | |
dc.contributor.author | Orlov, Y.L. | |
dc.contributor.author | Hong, S. | |
dc.contributor.author | Zhang, Z. | |
dc.contributor.author | Landt, S. | |
dc.contributor.author | Raha, D. | |
dc.contributor.author | Euskirchen, G. | |
dc.contributor.author | Wei, C.-L. | |
dc.contributor.author | Ge, W. | |
dc.contributor.author | Wang, H. | |
dc.contributor.author | Davis, C. | |
dc.contributor.author | Fisher-Aylor, K.I. | |
dc.contributor.author | Mortazavi, A. | |
dc.contributor.author | Gerstein, M. | |
dc.contributor.author | Gingeras, T. | |
dc.contributor.author | Wold, B. | |
dc.contributor.author | Sun, Y. | |
dc.contributor.author | Fullwood, M.J. | |
dc.contributor.author | Cheung, E. | |
dc.contributor.author | Liu, E. | |
dc.contributor.author | Sung, W.-K. | |
dc.contributor.author | Snyder, M. | |
dc.contributor.author | Ruan, Y. | |
dc.date.accessioned | 2013-07-04T07:36:25Z | |
dc.date.available | 2013-07-04T07:36:25Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Li, G., Ruan, X., Auerbach, R.K., Sandhu, K.S., Zheng, M., Wang, P., Poh, H.M., Goh, Y., Lim, J., Zhang, J., Sim, H.S., Peh, S.Q., Mulawadi, F.H., Ong, C.T., Orlov, Y.L., Hong, S., Zhang, Z., Landt, S., Raha, D., Euskirchen, G., Wei, C.-L., Ge, W., Wang, H., Davis, C., Fisher-Aylor, K.I., Mortazavi, A., Gerstein, M., Gingeras, T., Wold, B., Sun, Y., Fullwood, M.J., Cheung, E., Liu, E., Sung, W.-K., Snyder, M., Ruan, Y. (2012). Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell 148 (1-2) : 84-98. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cell.2011.12.014 | |
dc.identifier.issn | 00928674 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/39208 | |
dc.description.abstract | Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovered widespread promoter-centered intragenic, extragenic, and intergenic interactions. These interactions further aggregated into higher-order clusters, wherein proximal and distal genes were engaged through promoter-promoter interactions. Most genes with promoter-promoter interactions were active and transcribed cooperatively, and some interacting promoters could influence each other implying combinatorial complexity of transcriptional controls. Comparative analyses of different cell lines showed that cell-specific chromatin interactions could provide structural frameworks for cell-specific transcription, and suggested significant enrichment of enhancer-promoter interactions for cell-specific functions. Furthermore, genetically-identified disease-associated noncoding elements were found to be spatially engaged with corresponding genes through long-range interactions. Overall, our study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells. © 2012 Elsevier Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cell.2011.12.014 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | COMPUTER SCIENCE | |
dc.description.doi | 10.1016/j.cell.2011.12.014 | |
dc.description.sourcetitle | Cell | |
dc.description.volume | 148 | |
dc.description.issue | 1-2 | |
dc.description.page | 84-98 | |
dc.description.coden | CELLB | |
dc.identifier.isiut | 000299540700016 | |
Appears in Collections: | Staff Publications |
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