Please use this identifier to cite or link to this item: https://doi.org/10.1504/IJBRA.2012.048968
Title: Conservation of water molecules in protein binding interfaces
Authors: Li, Z.
He, Y.
Cao, L.
Wong, L. 
Li, J.
Keywords: Burial level
Conservation
Interface
Protein-protein interface
Substitution
Water
Issue Date: 2012
Source: Li, Z.,He, Y.,Cao, L.,Wong, L.,Li, J. (2012). Conservation of water molecules in protein binding interfaces. International Journal of Bioinformatics Research and Applications 8 (3-4) : 228-244. ScholarBank@NUS Repository. https://doi.org/10.1504/IJBRA.2012.048968
Abstract: The conservation of interfacial water molecules has only been studied in small data sets consisting of interfaces of a specific function. So far, no general conclusions have been drawn from large-scale analysis, due to the challenges of using structural alignment in large data sets. To avoid using structural alignment, we propose a solvated sequence method to analyse water conservation properties in protein interfaces. We first usewater information to label the residues, and then align interfacial residues in a fashion similar to normal sequence alignment. Our results show that, for a water-contacting interfacial residue, substituting it into hydrophobic residues tends to desolvate the local area. Surprisingly, residues with short side chains also tend not to lose their contacting water, emphasising the role of water in shaping binding sites. Deeply buried water molecules are found more conserved in terms of their contacts with interfacial residues. Copyright © 2012 Inderscience Enterprises Ltd.
Source Title: International Journal of Bioinformatics Research and Applications
URI: http://scholarbank.nus.edu.sg/handle/10635/39206
ISSN: 17445485
DOI: 10.1504/IJBRA.2012.048968
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