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|Title:||The role of miRNAs in complex formation and control|
|Citation:||Goh, W.W.B., Oikawa, H., Sng, J.C.G., Sergot, M., Wong, L. (2012). The role of miRNAs in complex formation and control. Bioinformatics 28 (4) : 453-456. ScholarBank@NUS Repository. https://doi.org/10.1093/bioinformatics/btr693|
|Abstract:||microRibonucleic acid (miRNAs) are small regulatory molecules that act by mRNA degradation or via translational repression. Although many miRNAs are ubiquitously expressed, a small subset have differential expression patterns that may give rise to tissue-specific complexes. Motivation: This work studies gene targeting patterns amongst miRNAs with differential expression profiles, and links this to control and regulation of protein complexes. Results: We find that, when a pair of miRNAs are not expressed in the same tissues, there is a higher tendency for them to target the direct partners of the same hub proteins. At the same time, they also avoid targeting the same set of hub-spokes. Moreover, the complexes corresponding to these hub-spokes tend to be specific and nonoverlapping. This suggests that the effect of miRNAs on the formation of complexes is specific. © The Author 2011. Published by Oxford University Press. All rights reserved.|
|Appears in Collections:||Staff Publications|
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