Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/38815
Title: MECHANISMS AND FUNCTIONS OF ADULT HIPPOCAMPAL NEUROGENESIS
Authors: WANG SHANGSHANG
Keywords: hippocampus, dentate gyrus, neurogenesis, theta rhythm, optogenetics, pattern separation
Issue Date: 21-Aug-2012
Source: WANG SHANGSHANG (2012-08-21). MECHANISMS AND FUNCTIONS OF ADULT HIPPOCAMPAL NEUROGENESIS. ScholarBank@NUS Repository.
Abstract: Adult neurogenesis is the process of birth of neurons in mature brains. It happens in particularly two regions of the brain. The subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus is one of the neurogenic niches, and is the main interest of this thesis. This study demonstrated that theta driven electrical stimulation (7Hz) in the medial septum area (MSA) resulted in a substantial increase of DG neural progenitor proliferation. The subsequent release of sonic hedgehog (Shh) via the septohippocampal pathway was responsible for this effect. Studies were also carried out to establish optogenetic animal models for the functional investigation of hippocampal neurogenesis. This study is a application of a retroviral expression system for optogenetic control on adult born DG neurons. Behavioral results showed that adult born mature neurons were important for associative learning and pattern separation.
URI: http://scholarbank.nus.edu.sg/handle/10635/38815
Appears in Collections:Ph.D Theses (Open)

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