Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/38762
Title: STRUCTURAL, MECHANICAL AND VISCOELASTIC CHANGES IN OVARIECTOMIZED RAT UPON DRUG TREATMENT AND VIBRATION THERAPY
Authors: YANG XIAO
Keywords: bone viscoelasticity,ibandronate,PTH,whole-body vibration,osteoporosis
Issue Date: 22-Aug-2012
Source: YANG XIAO (2012-08-22). STRUCTURAL, MECHANICAL AND VISCOELASTIC CHANGES IN OVARIECTOMIZED RAT UPON DRUG TREATMENT AND VIBRATION THERAPY. ScholarBank@NUS Repository.
Abstract: Viscoelastic properties, like viscosity, elastic modulus and loss tangent are crucial determinants of bone strength but seldom assessed in drug or whole-body vibration (WBV) therapy. In this thesis, beneficial effect of PTH and ibandronate combined treatment in ovariectomized rat bone was firstly revealed by BMD, biomarkers and mechanical test. Viscoelasticity of the bones were further examined using nanoindentation and dynamic mechanical analyzer. Combined treatment had better therapeutic effects in terms of increased viscosity and loss tangent. Besides drugs, WBV effect on BMD, mechanical and viscoelastic properties were also investigated. No substantial effect on BMD and viscoelasticity was found after 16 weeks of WBV. Maximum load was even significantly reduced in vibrated group. WBV should not be recommended for long-term usage. The results of the present work provide a better understanding of pathogenesis of osteoporosis and present a novel assessment of treatment efficacy in bone viscoelasticity aspect.
URI: http://scholarbank.nus.edu.sg/handle/10635/38762
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