Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/38753
Title: A STUDY ON STRUCTURAL, VISCOELASTIC PROPERTY AND OSTEOBLAST CHANGES IN OSTEOLYTIC METASTASES
Authors: CHEN XIULI
Keywords: Osteoblast, bone microstructure, viscoelasticity, osteolytic metastases
Issue Date: 22-Aug-2012
Source: CHEN XIULI (2012-08-22). A STUDY ON STRUCTURAL, VISCOELASTIC PROPERTY AND OSTEOBLAST CHANGES IN OSTEOLYTIC METASTASES. ScholarBank@NUS Repository.
Abstract: Osteolytic bone metastasis shows enhanced bone resorption and impaired bone formation. Sclerotic (tissue hardening) development is common but little is known about intrinsic mechanical property changes. The effect of tumour on bone cell mechanosensing and thus bone formation is also unknown. In this thesis, sclerotic bone response showed increased reactive bone formation and enhanced microarchitecture. Reduced creep effect was observed in both trabeculae and cortical bone. Viscoelastic nanomechanical property was shown to be a more sensitive indicator of bone modeling than elastic properties. Through primary tumor culture, sustained inhibition of bone cells viability, differentiation and mineralization was demonstrated. A significant decrease in stiffness of tumor conditioned bone cells first shown in this study was positively associated with cytoskeletal changes. Mechanosensitivity to vibration was demonstrated to be significantly decreased in tumour conditioned bone cells. Tumor inhibition of bone cells viability, functionality, mechanical property and mechanosensitivity could contribute to bone remodeling imbalance.
URI: http://scholarbank.nus.edu.sg/handle/10635/38753
Appears in Collections:Ph.D Theses (Open)

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