Please use this identifier to cite or link to this item:
|Title:||Biomechanical strength of deep-frozen versus lyophilized large cortical allografts|
|Authors:||Nather, A. |
|Source:||Nather, A., Thambyah, A., Goh, J.C.H. (2004). Biomechanical strength of deep-frozen versus lyophilized large cortical allografts. Clinical Biomechanics 19 (5) : 526-533. ScholarBank@NUS Repository. https://doi.org/10.1016/j.clinbiomech.2004.01.010|
|Abstract:||Objective. To compare biomechanical strength of deep-frozen versus lyophilized large cortical allografts. Design. In vivo transplantation studies performed in tibia of adult cats using 4 cm deep-frozen and lyophilized, gamma-irradiated allografts to bridge large cortical defect model. Background. Bridging large cortical bone defect is a challenging problem. Options include autografts, allografts, bioceramics and prostheses. Allografts provide a suitable option. Methods. Forty mature cats were used. A large defect (4 cm) was created in mid-diaphysis of right tibia. In 16 cats, cortical defect was reconstructed using deep-frozen allografts (-80°C) with intra-medullary rodding. In another 16 cats, lyophilized, gamma-irradiated allografts were used. Observation periods include 8, 12, 16 and 24 weeks. The specimens were procured together with unoperated legs as controls. Mechanical testing was performed using a materials testing machine with torsion test device of up to 500 Nm at speed of 0.18 rpm. Parameters studied included maximum torque, torsional stiffness and energy of absorption. Results. Deep-frozen allografts did not reach 100% strength, achieving only 64% at 6 months. In marked contrast, lyophilized allografts were significantly weaker with only 12% maximum torque strength at 6 months. Lyophilized allografts were significantly weaker than deep-frozen allografts in all observation periods (p<0.05). Conclusion. Deep-frozen allografts did not reach 100% normal strength and were significantly weaker than non-vascularised autografts. Lyophilized allografts were significantly weaker than deep-frozen allografts.Relevance For the reconstruction of massive cortical bone defects, only deep-frozen cortical allografts should be used. Lyophilized allografts are not suitable. © 2004 Elsevier Ltd. All rights reserved.|
|Source Title:||Clinical Biomechanics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 5, 2018
WEB OF SCIENCETM
checked on Mar 5, 2018
checked on Feb 25, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.