Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/38384
Title: INVESTIGATION OF AN ATYPICAL MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY IN PLASMODIUM FALCIPARUM
Authors: LOW HUIYU
Keywords: Malaria, Plasmodium falciparum, MAPK, MAPKK, Phosphorylation, Regulation
Issue Date: 22-Feb-2013
Source: LOW HUIYU (2013-02-22). INVESTIGATION OF AN ATYPICAL MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY IN PLASMODIUM FALCIPARUM. ScholarBank@NUS Repository.
Abstract: Mitogen-activated protein kinase (MAPK) pathways are essential in eukaryotes for regulating cell growth and proliferation. While MAPK pathways are well-characterized in numerous eukaryotes, much less is known about the corresponding pathways in Plasmodium falciparum, the most deadly malaria-causing parasite. So far, analyses of its kinome could identify only homologues of the MAPKs (Pfmap1 and Pfmap2), but not those of the MAPK Kinases (MAPKKs) and MAPKK Kinases (MAPKKKs). Nonetheless, a P. falciparum NIMA-like kinase, Pfnek3, has previously been found to be competent in activating Pfmap2 through phosphorylation of the threonine residue within the TSH activation site. As this functionality coincides with that expected of a MAPKK, Pfnek3 was consequently recognized as a unique MAPKK in P. falciparum. In this project, further characterization of Pfnek3 was pursued to gain deeper insights into this unique MAPKK of P. falciparum. In addition, an investigation was initiated to identify interacting partners of Pfnek3 and Pfmap2.
URI: http://scholarbank.nus.edu.sg/handle/10635/38384
Appears in Collections:Ph.D Theses (Open)

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