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|Title:||Interferon-β administration confers a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia|
|Source:||Liu, H., Xin, L., Teoh, R., Tang, B.L., Tan, Y.H, Chan, B.P.L. (2002). Interferon-β administration confers a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia. Neuroscience Letters 327 (2) : 146-148. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(02)00371-3|
|Abstract:||We demonstrate that treatment with the cytokine human interferon-β (IFN-β) resulted in a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia. Rabbits administered subcutaneously with IFN-β prior to (pre-treatment) or after (post-treatment) the introduction of an autologous blood clot into the middle cerebral artery have consistently smaller subcortical infarct volumes compared to control (untreated) counterparts. The average subcortical infarct volume of pre-treatment rabbits is 46.3±9.3 mm3 (n=4), and that of post-treatment rabbit is 40.0±23.1 mm3 (n=4). Both are significantly lower (P=0.003 and P=0.004, respectively) than the average subcortical infarct volume of control rabbits (121.6±32.9 mm3, n=5). Although the precise mechanism responsible for the beneficial effect of IFN-β on stroke is not yet clear, our results are in line with the known anti-inflammatory potential and anti-apoptotic function of IFN-β. © 2002 Elsevier Science Ireland Ltd. All rights reserved.|
|Source Title:||Neuroscience Letters|
|Appears in Collections:||Staff Publications|
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