Interferon-β administration confers a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia
Liu, H. Xin, L. Teoh, R. Tang, B.L. Tan, Y.H Chan, B.P.L.
Liu, H.
Xin, L.
Teoh, R.
Tan, Y.H
Chan, B.P.L.
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Abstract
We demonstrate that treatment with the cytokine human interferon-β (IFN-β) resulted in a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia. Rabbits administered subcutaneously with IFN-β prior to (pre-treatment) or after (post-treatment) the introduction of an autologous blood clot into the middle cerebral artery have consistently smaller subcortical infarct volumes compared to control (untreated) counterparts. The average subcortical infarct volume of pre-treatment rabbits is 46.3±9.3 mm3 (n=4), and that of post-treatment rabbit is 40.0±23.1 mm3 (n=4). Both are significantly lower (P=0.003 and P=0.004, respectively) than the average subcortical infarct volume of control rabbits (121.6±32.9 mm3, n=5). Although the precise mechanism responsible for the beneficial effect of IFN-β on stroke is not yet clear, our results are in line with the known anti-inflammatory potential and anti-apoptotic function of IFN-β. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keywords
Animal model, Interferon, Ischemia, Stroke
Source Title
Neuroscience Letters
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Series/Report No.
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Date
2002
DOI
10.1016/S0304-3940(02)00371-3
Type
Article