Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells

Please use this identifier to cite or link to this item: https://doi.org/10.1016/0304-3835(92)90099-H

Title:	Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells
Authors:	Ramanathan, R. Tan, C.H. Das, N.P.
Keywords:	Cytotoxic effect Fat-soluble vitamins Flavonoids Hela Polyphenols Raji
Issue Date:	1992
Citation:	Ramanathan, R., Tan, C.H., Das, N.P. (1992). Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells. Cancer Letters 62 (3) : 217-224. ScholarBank@NUS Repository. https://doi.org/10.1016/0304-3835(92)90099-H
Abstract:	In vitro studies showed that several flavonoids, tannic acid, gallic acid and fat-soluble vitamins inhibited HeLa and Raji lymphoma cell growth. The inhibition trend exhibited by these compounds was similar for both cell lines, and their growth was inhibited dose dependently. Butein, (10 μM), the most potent anti-proliferative agent, exerted 30 % growth inhibition and was more effective on HeLa cells. Retinol (100 μM) inhibited cell proliferation completely. Tannic acid was twice as potent as its monomer gallic acid. From structure-activity consideration, the C2,3-double bond of the flavonoid molecule was important for activity. Flavonoid aglycones were more effective than their corresponding glycosides in suppressing cell growth.
Source Title:	Cancer Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/38274
ISSN:	03043835
DOI:	10.1016/0304-3835(92)90099-H
Appears in Collections:	Staff Publications

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