Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1534-5807(04)00097-8
Title: Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain
Authors: Cheng, Y.-C.
Amoyel, M.
Wilkinson, D.G.
Xu, Q.
Qiu, X.
Jiang, Y.-J. 
Issue Date: 2004
Source: Cheng, Y.-C., Amoyel, M., Wilkinson, D.G., Xu, Q., Qiu, X., Jiang, Y.-J. (2004). Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Developmental Cell 6 (4) : 539-550. ScholarBank@NUS Repository. https://doi.org/10.1016/S1534-5807(04)00097-8
Abstract: During segmentation of the vertebrate hindbrain, a distinct population of boundary cells forms at the interface between each segment. Little is known regarding mechanisms that regulate the formation or functions of these cells. We have investigated a potential role of Notch signaling and find that in the zebrafish hindbrain, radical fringe is expressed in boundary cells and delta genes are expressed adjacent to boundaries, consistent with a sustained activation of Notch in boundary cells. Mosaic expression experiments reveal that activation of the Notch/Su(H) pathway regulates cell affinity properties that segregate cells to boundaries. In addition, Notch signaling correlates with a delayed neurogenesis at hindbrain boundaries and is required to inhibit premature neuronal differentiation of boundary cells. These findings reveal that Notch activation couples the regulation of location and differentiation in hindbrain boundary cells. Such coupling may be important for these cells to act as a stable signaling center. © 2004 by Cell Press.
Source Title: Developmental Cell
URI: http://scholarbank.nus.edu.sg/handle/10635/38248
ISSN: 15345807
DOI: 10.1016/S1534-5807(04)00097-8
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

83
checked on Jan 23, 2018

WEB OF SCIENCETM
Citations

84
checked on Jan 8, 2018

Page view(s)

72
checked on Jan 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.