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Title: Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus
Authors: Rehman, A.
Halliwell, B. 
Nourooz-Zadeh, J.
Moller, W.
Tritschler, H.
Pereira, P.
Keywords: Diabetes
DNA damage
Hydroxyl radical
Oxidative stress
Issue Date: 1999
Citation: Rehman, A., Halliwell, B., Nourooz-Zadeh, J., Moller, W., Tritschler, H., Pereira, P. (1999). Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus. FEBS Letters 448 (1) : 120-122. ScholarBank@NUS Repository.
Abstract: Gas chromatography-mass spectrometry was used to measure the oxidative DNA damage in diabetic subjects and controls. Levels of multiple DNA base oxidation products, but not DNA base de-amination or chlorination products, were found to be elevated in white blood cell DNA from patients with type II diabetes as compared with age-matched controls. The chemical pattern of base damage is characteristic of that caused by an attack on DNA by hydroxyl radical. An increased formation of the highly reactive hydroxyl radical could account for many of the reports of oxidative stress in diabetic subjects. There was no evidence of an increased DNA damage by reactive nitrogen or chlorine species. Copyright (C) 1999 Federation of European Biochemical Societies.
Source Title: FEBS Letters
ISSN: 00145793
DOI: 10.1016/S0014-5793(99)00339-7
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