Please use this identifier to cite or link to this item: https://doi.org/10.1016/0006-291X(92)90470-6
Title: Adenosine modulates cell growth in human epidermoid carcinoma (A431) cells
Authors: Tey, H.B.
Khoo, H.E. 
Tan, C.H. 
Issue Date: 1992
Citation: Tey, H.B., Khoo, H.E., Tan, C.H. (1992). Adenosine modulates cell growth in human epidermoid carcinoma (A431) cells. Biochemical and Biophysical Research Communications 187 (3) : 1486-1492. ScholarBank@NUS Repository. https://doi.org/10.1016/0006-291X(92)90470-6
Abstract: Adenosine mediates many physiological functions via activation of extracellular receptors. The modulation of cell growth by adenosine was found to be receptor-mediated. In A431 cells adenosine evoked a biphasic response in which a low concentration (~10 μM) produced inhibition of colony formation but at higher concentrations (up to 100 μM) this inhibition was progressively reversed. Evidence for the involvement of A1 (inhibitory) and A2 (stimulatory) adenosine receptors in regulating cell growth of these tumor cells was obtained through plating efficiency studies based on the relative potency of adenosine agonists and antagonists. When both A1 and A2 receptors were blocked, colony formation or growth was not inhibited at low concentrations of adenosine but was inhibited at high adenosine concentrations.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/38233
ISSN: 0006291X
DOI: 10.1016/0006-291X(92)90470-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

33
checked on Oct 15, 2018

WEB OF SCIENCETM
Citations

33
checked on Oct 15, 2018

Page view(s)

82
checked on Sep 29, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.