Please use this identifier to cite or link to this item: https://doi.org/10.1016/0885-4505(91)90023-E
Title: Does calmodulin mediate inhibition of human erythrocyte Ca2+-pumping ATPase by myricetin?
Authors: Teo, T.-S. 
Thiyagarajah, P. 
Wong, Z.-Z.
Das, N.-P.
Issue Date: 1991
Source: Teo, T.-S., Thiyagarajah, P., Wong, Z.-Z., Das, N.-P. (1991). Does calmodulin mediate inhibition of human erythrocyte Ca2+-pumping ATPase by myricetin?. Biochemical Medicine and Metabolic Biology 45 (2) : 209-215. ScholarBank@NUS Repository. https://doi.org/10.1016/0885-4505(91)90023-E
Abstract: Myricetin, a flavonoid, potently inhibits human erythrocyte plasma membrane Ca2+-pumping ATPase activity: half-maximal inhibition of the basal and calmodulin-stimulated activity is obtained with 6 μM myricetin. Inhibition of the Ca2+-ATPase by myricetin is observed at all concentrations of free Ca2+ from 10-8M to 10-5M. The extent of inhibition of the Ca2+-ATPase is dependent on the time of preincubation of the plasma membranes with myricetin. Inhibition of the Ca2+-ATPase by myricetin is not reversed by excess calmodulin. It is concluded that calmodulin does not mediate myricetin's inhibition of human erythrocyte plasma membrane Ca2+-pumping ATPase.
Source Title: Biochemical Medicine and Metabolic Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/38225
ISSN: 08854505
DOI: 10.1016/0885-4505(91)90023-E
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