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|Title:||Calcium ion activation of the anion-conducting channel in the rat liver mitochondrial inner membrane|
|Authors:||Selwyn, M.J. |
Mitochondrial inner membrane
|Citation:||Selwyn, M.J., Ng, C.L.T., Choo, H.L. (1990). Calcium ion activation of the anion-conducting channel in the rat liver mitochondrial inner membrane. FEBS Letters 269 (1) : 205-208. ScholarBank@NUS Repository. https://doi.org/10.1016/0014-5793(90)81155-H|
|Abstract:||Stimulation of the rat liver mitochondrial inner-membrane anion-conducting channel by aeration is dependent on the concentration of Ca2+ ions in the assay medium. Ca2+ activates anion conduction in both aerated and non-energised mitochondria but acts over a wider concentration range and produces a greater increase in anion-conductivity in aerated mitochondria. EGTA reverse Ca2+ stimulation but takes several seconds to act, indicating slow release of Ca2+ from the activation site possibly on the matrix side of the inner mitochondrial membrane. It is suggested that this channel may respond to hormone-induced changes in cytosolic Ca2+ concentration.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
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