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|Title:||The pH-dependent anion-conducting channel of the mitochondrial inner membrane is potently inhibited by zinc ions|
|Authors:||Selwyn, M.J. |
mitochondrial inner membrane
|Citation:||Selwyn, M.J., Ng, L.T., Choo, H.L. (1993). The pH-dependent anion-conducting channel of the mitochondrial inner membrane is potently inhibited by zinc ions. FEBS Letters 331 (1-2) : 129-133. ScholarBank@NUS Repository. https://doi.org/10.1016/0014-5793(93)80311-H|
|Abstract:||Zinc is a potent reversible inhibitor of the pH-dependent anion-conducting channel in the mitochondrial inner membrane, 50% inhibition was produced by 1.5 μM added Zn2+ at which point free Zn2+ was ≤10-8 M. Inhibition by Zn2+ is rapid but can be prevented or rapidly reversed by excess EDTA. Concentrations of Zn2+ higher than 4 μM caused reversal of inhibition to a variable extent depending on the anion. Under these conditions Zn2+ did not inhibit ribose entry, the phosphate transporter,or the pH-insensitive component of the NO3- uniport.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
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