Please use this identifier to cite or link to this item: https://doi.org/10.1016/0014-5793(93)80311-H
Title: The pH-dependent anion-conducting channel of the mitochondrial inner membrane is potently inhibited by zinc ions
Authors: Selwyn, M.J. 
Ng, L.T. 
Choo, H.L.
Keywords: anion channel
anion uniport
inhibition
mitochondrial inner membrane
mitochondrion
zinc
Issue Date: 1993
Source: Selwyn, M.J., Ng, L.T., Choo, H.L. (1993). The pH-dependent anion-conducting channel of the mitochondrial inner membrane is potently inhibited by zinc ions. FEBS Letters 331 (1-2) : 129-133. ScholarBank@NUS Repository. https://doi.org/10.1016/0014-5793(93)80311-H
Abstract: Zinc is a potent reversible inhibitor of the pH-dependent anion-conducting channel in the mitochondrial inner membrane, 50% inhibition was produced by 1.5 μM added Zn2+ at which point free Zn2+ was ≤10-8 M. Inhibition by Zn2+ is rapid but can be prevented or rapidly reversed by excess EDTA. Concentrations of Zn2+ higher than 4 μM caused reversal of inhibition to a variable extent depending on the anion. Under these conditions Zn2+ did not inhibit ribose entry, the phosphate transporter,or the pH-insensitive component of the NO3- uniport.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/38163
ISSN: 00145793
DOI: 10.1016/0014-5793(93)80311-H
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