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https://doi.org/10.1016/S0378-1119(00)00365-6
Title: | Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo | Authors: | Duan, W. Sun, B. Li, T.W. Tan, B.J. Lee, M.K. Teo, T.S. |
Keywords: | PKN Protein-protein interaction Signal transduction |
Issue Date: | 2000 | Citation: | Duan, W., Sun, B., Li, T.W., Tan, B.J., Lee, M.K., Teo, T.S. (2000). Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. Gene 256 (1-2) : 113-121. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-1119(00)00365-6 | Abstract: | We describe the cloning and expression of cDNAs encoding a novel human protein of 208 amino acid residues with a predicted molecular mass of 22.6kDa and its mouse homologue. We name this protein as AWP1 (associated with PRK1). AWP1 is a ubiquitously expressed protein, and the Awp1 gene is switched on during early human and mouse development. When expressed in COS-1 cells, the Myc-tagged AWP1 has an apparent molecular mass higher than that deduced from its amino acid sequence. AWP1 possesses a conserved zf-A20 zinc finger domain at its N-terminal and a zf-AN1 zinc finger domain at its C-terminal. Co-immunoprecipitation experiments revealed that mouse AWP1 specifically interacts with a rat serine/threonine protein kinase PRK1 in vivo. Hence, AWP1 may play a regulatory role in mammalian signal transduction pathways. Copyright (C) 2000 Elsevier Science B.V. | Source Title: | Gene | URI: | http://scholarbank.nus.edu.sg/handle/10635/38162 | ISSN: | 03781119 | DOI: | 10.1016/S0378-1119(00)00365-6 |
Appears in Collections: | Staff Publications |
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