Please use this identifier to cite or link to this item: https://doi.org/10.1016/0041-0101(95)00069-X
Title: Effects of sea anemone (Heteractis magnifica and Actinia equina) cytolysins on synaptosomal uptake of GABA and choline
Authors: Khoo, H.E. 
Lim, J.P.C.
Tan, C.H. 
Issue Date: 1995
Source: Khoo, H.E., Lim, J.P.C., Tan, C.H. (1995). Effects of sea anemone (Heteractis magnifica and Actinia equina) cytolysins on synaptosomal uptake of GABA and choline. Toxicon 33 (10) : 1365-1371. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(95)00069-X
Abstract: Magnificalysin I and II (HMg I and II) and equinatoxin II (EqTx II) are cytolytic toxins extracted from sea anemones Heteractis magnfica and Actinia equina, respectively. They induced haemolysis in rat red blood cells and inhibited gamma amino butyric acid (GABA) and choline uptake into rat brain synaptosomes. These effects were concentration dependent. The inhibition of GABA and choline uptake could be overcome by the addition of exogeneous sphingomyelin, suggesting that there might be interaction between these cytolysins and the phospholipid. Although the precise mechanisms involved in haemolysis and inhibition of GABA and choline uptake are unknown, they appeared to be different.
Source Title: Toxicon
URI: http://scholarbank.nus.edu.sg/handle/10635/38114
ISSN: 00410101
DOI: 10.1016/0041-0101(95)00069-X
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