Please use this identifier to cite or link to this item: https://doi.org/10.1016/0041-0101(95)00028-K
Title: Bioactivity and mechanism of action of Lophozozymus pictor toxin
Authors: Lau, C.O.
Tan, C.H. 
Li, Q.T. 
Ng, F.H.
Yuen, R.
Khoo, H.E. 
Issue Date: 1995
Citation: Lau, C.O., Tan, C.H., Li, Q.T., Ng, F.H., Yuen, R., Khoo, H.E. (1995). Bioactivity and mechanism of action of Lophozozymus pictor toxin. Toxicon 33 (7) : 901-908. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(95)00028-K
Abstract: The bioactivity of Lophozozymus pictor toxin (LPTX) and the possible mechanism of action of the purified toxin are described. LPTX is found to possess palytoxin-like bioactivities. Besides exhibiting cytotoxic and haemolytic properties, LPTX causes the release of K+ from erythrocytes and inhibits 2-[14C]deoxy-d-glucose uptake into HeLa cells. Although LPTX acts on HeLa cell and erythrocyte membranes, it does not interact with mitochondrial or liposomal membranes containing different phospholipid compositions. Ouabain, but not sphingomyelin, is able to prevent the toxic effects of LPTX. This antagonistic effect of ouabain on LFTX suggests that the toxin might mediate its toxic effects via the membrane Na+/K+-ATPase but not through interaction with membrane lipids.
Source Title: Toxicon
URI: http://scholarbank.nus.edu.sg/handle/10635/38109
ISSN: 00410101
DOI: 10.1016/0041-0101(95)00028-K
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on Sep 20, 2018

WEB OF SCIENCETM
Citations

6
checked on Sep 10, 2018

Page view(s)

91
checked on Sep 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.