Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37896
Title: Single-Channel and whole-cell electrophysiological characterizations of L-Type Cav1.2 Calcium channel splice variants: Relevance to cardiac and nervous system functions
Authors: PETER BARTELS
Keywords: Calcium channels, CaV1.2 isoforms, alternative splicing, single-channel recordings
Issue Date: 4-Jan-2013
Source: PETER BARTELS (2013-01-04). Single-Channel and whole-cell electrophysiological characterizations of L-Type Cav1.2 Calcium channel splice variants: Relevance to cardiac and nervous system functions. ScholarBank@NUS Repository.
Abstract: The L-type CaV1.2 calcium channel forms a hetero-oligomeric complex which is comprised of a transmembrane pore-forming ?1-subunit, associated and modulated by auxiliary ?- and ?2?-subunits. CaV1.2 channels are abundantly expressed in the cardiovascular and nervous systems where their activation initiates a rapid influx of Ca2+ ions through their membrane spanning pores, triggering various cell responses such as excitation-contraction coupling in the heart muscle, gene expression and synaptic plasticity in the CNS. Alternative splicing of CaV1.2 has been associated with changes in the electrophysiological and pharmacological properties of the channel (Liao et al., 2007; Liao et al., 2004; Tang et al., 2004)and is furthermore implicated in severe cardiovascular and neuronal dysfunctions. This PhD thesis focuses on how the significance of alternative splicing in generating channel functional diversity could be evaluated by using an in vitro expression system as well as a more complex ex vivo system...
URI: http://scholarbank.nus.edu.sg/handle/10635/37896
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