Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37895
Title: SEQUENTIAL PDGF-SIMVASTATIN RELEASE TO PROMOTE DENTOALVEOLAR REGENERATION
Authors: CHONG LI YEN
Keywords: platelet derived growth factor (PDGF), simvastatin, dentoalveolar regeneration, osseous defect, microspheres, control release
Issue Date: 27-Dec-2012
Source: CHONG LI YEN (2012-12-27). SEQUENTIAL PDGF-SIMVASTATIN RELEASE TO PROMOTE DENTOALVEOLAR REGENERATION. ScholarBank@NUS Repository.
Abstract: This thesis aimed at designing and fabricating a delivery system to sequential release platelet-derived growth factor (PDGF, mitogen) and simvastatin (osteogenic differentiation promoter), in order to promote dentoalveolar regeneration. Coaxial electrohydrodynamic atomization technique was utilized to fabricate double-walled PLGA(PDLLA) microspheres. The microspheres have rounded morphology with distinct core-shell structure and high encapsulating efficiency. A fast-release of PDGF followed by slow-release of simvastatin was noted in simvastatin-in-core/PDGF-in-shell(SP)-microspheres. All microspheres demonstrated acceptable biocompatibility in vivo, with increased proliferation, reduced apoptosis, and reduced inflammation while PDGF or simvastatin was encapsulated. From micro-CT assessment, SP-treated-specimens demonstrated highest bone volume fraction, tissue mineral density, trabecular thickness, and trabecular number at day 14. Descriptive histology revealed more trabecular bone formation in SP-treated-specimens at day 14, and bone maturation was noted at day 28. We successfully fabricated microspheres with sequential releasing profile of PDGF and simvastatin which improve biocompatibility and promote dentoalveolar regeneration in a preclinical model.
URI: http://scholarbank.nus.edu.sg/handle/10635/37895
Appears in Collections:Master's Theses (Open)

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