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Title: The role of Prion Protein in Breast Cancer cell metabolism
Keywords: Prion, Prion protein, Breast cancer, metabolism, cancer, Warburg effect
Issue Date: 31-May-2012
Citation: WONG HUIMIN IRA (2012-05-31). The role of Prion Protein in Breast Cancer cell metabolism. ScholarBank@NUS Repository.
Abstract: Breast cancer is the major cause of cancer death in women in Singapore. The current paucity of early diagnostic markers, calls for a need to further understand the aetiology of breast cancer to provide better treatment and prevention. Breast cancer cells have been shown to exhibit the Warburg effect characterised by increased levels of glycolytic enzymes, glucose consumption and lactate production. Prion protein (PrP), known to cause neurodegenerative prion disease in human has also been implicated in cancer progression. In this project, we assessed the effect of PrP in breast cancer cells using two PrP over-expressing cell lines. We found that increased PrP expression was associated with reduced proliferation rate. Our results, while preliminary, showed that PrP is associated with phosphorylated Akt at serine 473 reducing glucose transporter 4 expression, resulting in increased lactate production. We speculate that PrP modulates breast cancer metabolism and is likely to be linked to the Warburg effect.
Appears in Collections:Master's Theses (Open)

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