Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37843
Title: THE ROLE OF D-PTX1 IN DROSOPHILA NEURONAL DEVELOPMENT
Authors: TOH YONG EN JOANNE
Keywords: Drosophila, Nervous System, interneuron specification
Issue Date: 21-Aug-2012
Source: TOH YONG EN JOANNE (2012-08-21). THE ROLE OF D-PTX1 IN DROSOPHILA NEURONAL DEVELOPMENT. ScholarBank@NUS Repository.
Abstract: Neuronal identity is determined by the expression of specific combination of transcription factors. Although approximately 80% of cells in the CNS are interneurons, not much is known about their development compared to motorneurons. In the central nervous system, D-Ptx1 is expressed exclusively in interneurons and in some lineages, D-Ptx1+ interneurons shared sibling relationships with dHb9+ motoneurons as opposing effects on dHb9+ motoneurons and D-Ptx1+ interneurons were observed in sanpodo or numb mutants. This indicated a possible role of asymmetric cell division in establishing the non-overlapping nature of D-Ptx1 and dHb9 expression in these lineages. Increased dHb9 expression in D-Ptx1 mutant embryos and repression of dHb9 expression when D-Ptx1 was mis-expressed demonstrated that D-Ptx1 is required and sufficient for interneuronal specification and suppression of the motoneuronal fate in some sibling cell neurons. From these experiments, we concluded that D-Ptx1 might be a regulator of interneuronal cell fate specification in a subset of interneurons.
URI: http://scholarbank.nus.edu.sg/handle/10635/37843
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