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Title: Photophysical investigation and pharmaceutical applications of chlorin e6 in biodegradable carriers
Keywords: Chlorin e6, photodynamic therapy, fluorescence spectroscopy, thermodynamics, molecular simulation, nanosuspension
Issue Date: 23-Jan-2013
Source: SHUBHAJIT PAUL (2013-01-23). Photophysical investigation and pharmaceutical applications of chlorin e6 in biodegradable carriers. ScholarBank@NUS Repository.
Abstract: Photodynamic therapy (PDT) is a popular treatment modality for cancer as it is non-invasive, inexpensive and able to produce targeted effect. Chlorin e6 has widely been used as photosensitizer of interest, but the PDT efficacy of Ce6 is largely limited due to aggregate formation. In addition, strong hydrophobicity of Ce6 adversely affects its bioavailability. In this study, it was hypothesized that aggregation of Ce6 could be prevented by using suitable pharmaceutical adjuvants, and these adjuvants could also be used as drug carrier for Ce6 if appropriately formulated. Using UV-VIS and fluorescence spectroscopic methods, the influence of physicochemical factors and pharmaceutical adjuvants on aggregate formation of Ce6 was extensively studied. Polyvinylpyrolidone (PVP), and sucrose ester surfactants were found to be effective disaggregating agents for Ce6. These adjuvants were used in the preparation of nanoparticulate formulation of Ce6, which significantly enhanced PDT efficacy when tested against oral carcinoma cells.
Appears in Collections:Ph.D Theses (Open)

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