Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37723
Title: ELUCIDATING THE ROLE OF BNIP-2 IN ZEBRAFISH EARLY DEVELOPMENT
Authors: CHUA SEE KIN DOREEN
Keywords: Bnip-2,zebrafish,E-cadherin,RhoA,gastrulation,morpholino
Issue Date: 24-Jan-2013
Source: CHUA SEE KIN DOREEN (2013-01-24). ELUCIDATING THE ROLE OF BNIP-2 IN ZEBRAFISH EARLY DEVELOPMENT. ScholarBank@NUS Repository.
Abstract: BNIP-2, first discovered as an interacting partner of the pro-survival Bcl-2 and viral E1B 19kDa protein, has been shown in cellular model systems to be involved in various signalling pathways leading to cell growth, apoptosis, morphogenesis and differentiation. In order to explore its potential role in development to gain further insight into its physiological function, functional studies on bnip-2 were conducted using morpholino-based knockdown in zebrafish. bnip-2 morphants display classical characteristics of gastrulation defects that are a result of perturbed regulation of key molecular players in cell dynamics as revealed by cellular and biochemical assays. This work contributes to knowledge on the genetic interactions of bnip-2 and the molecular mechanisms of zebrafish gastrulation involving bnip-2.
URI: http://scholarbank.nus.edu.sg/handle/10635/37723
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ChuaSKD.pdf9.09 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

196
checked on Dec 11, 2017

Download(s)

60
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.