Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37643
Title: INFLAMMATORY BIOMARKERS IN STROKE AND DEMENTIA
Authors: MA LU
Keywords: inflammation, biomarkers, ischemic stroke, prognosis
Issue Date: 14-Aug-2012
Source: MA LU (2012-08-14). INFLAMMATORY BIOMARKERS IN STROKE AND DEMENTIA. ScholarBank@NUS Repository.
Abstract: Peripheral inflammation correlates with stroke outcomes. Previous studies were conducted at the acute stage, when stroke severity, which itself predicts outcome, strongly correlates with inflammatory biomarkers. In¿ammation is also implicated in cognitive deterioration. Therefore, the present thesis evaluated the prognostic values of inflammatory biomarkers in non-disabled stroke survivors at the convalescent stage. 311 patients within six months of minor ischemic stroke were followed for up to five years. Baseline sera were collected at a median of 47 days after index events. Cox regressions were performed to associate biomarkers with death, recurrent vascular events, dependency, and incident dementia; logistic regressions were performed to associate biomarkers with significant cognitive decline. sVCAM-1 predicted death (HR, 1.85; 95% CI, 1.07-3.19) and recurrent stroke (HR 1.62; 95% CI, 1.08-2.41). PDGF-AB/BB predicted recurrent vascular events (HR, 0.60; 95% CI, 0.42-0.85). VEGF predicted significant cognitive decline (OR, 0.45; 95% CI, 0.26-0.77). Other biomarkers did not predict outcome.
URI: http://scholarbank.nus.edu.sg/handle/10635/37643
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