Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37583
Title: Gene Expression profiling in a rat model of neurodegeneration
Authors: NG PEI ERN MARY
Keywords: Excitotoxicity, kainic acid, chemokine, CCR2 antagonist, neurodegeneration, temporal gene expression
Issue Date: 31-Jul-2012
Source: NG PEI ERN MARY (2012-07-31). Gene Expression profiling in a rat model of neurodegeneration. ScholarBank@NUS Repository.
Abstract: Excitotoxicity is a pathological process involved in several neurodegenerative diseases. A few common genes suggest similar processes and mechanisms underlying these diseases. The present study was carried out to examine global gene expression changes in a rat kainate injection model. The right hippocampus was harvested at 1, 14 and 28 days post-injection and analyzed by microarray. Genes were mapped to networks using Ingenuity Pathways Analysis and findings from the networks were consistent with other studies in inflammation progression. Several chemokines such as Ccl2 and Ccl7 were also highly up-regulated at the 1 day time point. Further to these findings, KA-treated rats treated with Ccr2 antagonist resulted in an increase in neuronal survival marker NeuN, suggesting neuroprotection. These findings provide molecular insight into the contribution of chemokines and their receptors in excitotoxic injury involved in neurodegenerative diseases, and highlight the role of neuronal chemokines and their receptors in the injury process.
URI: http://scholarbank.nus.edu.sg/handle/10635/37583
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