Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/37550
Title: | Investigating neurotrophic factors that regulate axonal regeneration in muscle lacerations | Authors: | HAN HWAN CHOUR | Keywords: | intra-muscular nerve damage, lacerated skeletal muscles, neurotrophic factors, muscle atrophy, axonal regeneration, muscle fibrosis | Issue Date: | 14-Aug-2012 | Citation: | HAN HWAN CHOUR (2012-08-14). Investigating neurotrophic factors that regulate axonal regeneration in muscle lacerations. ScholarBank@NUS Repository. | Abstract: | The functional recovery of lacerated skeletal muscles is slow and incomplete, dependent on the integrity of the intra-muscular nerve. This study investigates gene and protein expression profiles of neurotrophic factors, atrophic factors and fibrosis factors during the early (2-weeks) and late phase (12-weeks) of repair using the medial gastrocnemius of adult male Sprague-Dawley rats. It is hypothesized that specific endogenous anti-fibrosis, anti-atrophic and pro-muscle re-innervation factors improve muscle and axonal regeneration in the early phase post-laceration. The mRNA and protein expression levels of targets in lacerated muscle models involving three different intramuscular nerve injuries were studied. In lacerated skeletal muscles with the intra-muscular nerve preserved intact, high expression levels of NT4, GDNF, CNTF, EGF, IGF1, HGF and Galectin-1 significantly enhanced the muscle regeneration via reduction in fibrosis and atrophy over 12-weeks post-laceration. This offers a rationale for targeting these factors to improve the recovery of lacerated skeletal muscles. | URI: | http://scholarbank.nus.edu.sg/handle/10635/37550 |
Appears in Collections: | Master's Theses (Open) |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
HANHC.pdf | 3.71 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.