Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/37426
Title: THE IMPORTANCE OF AN ALLOSTERIC POCKET IN THE DENGUE PROTEASE
Authors: NOEMI REBECCA MEIER
Keywords: Dengue,Protease,Allosteric Pocket,
Issue Date: 26-Dec-2012
Source: NOEMI REBECCA MEIER (2012-12-26). THE IMPORTANCE OF AN ALLOSTERIC POCKET IN THE DENGUE PROTEASE. ScholarBank@NUS Repository.
Abstract: Dengue is an emerging mosquito-borne viral infection with an estimated 2.5 billion people being at risk. The virus is found in tropical and subtropical areas around the globe and is transmitted by the main vector Aedes aegypti. According to WHO there are an estimated 50-100 million infections every year worldwide with an estimated 500'000 cases being hospitalized annually. Currently there is no treatment available, thus there is an urgent need for discovering new drugs. The dengue NS3 Serine Protease is a promising target for new drugs since it is involved in viral polyprotein processing together with the cofactor NS2B and thus important for the viral replication. The aim of my study is to mutate different residues within this protease and assess its effect on enzymatic activity and infectivity using different assays.
URI: http://scholarbank.nus.edu.sg/handle/10635/37426
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