Please use this identifier to cite or link to this item:
|Title:||Evacuation interval after vaginal misoprostol for preabortion cervical priming: A randomized trial|
|Authors:||Singh, K. |
|Citation:||Singh, K., Fong, Y.F., Prasad, R.N.V., Dong, F. (1999). Evacuation interval after vaginal misoprostol for preabortion cervical priming: A randomized trial. Obstetrics and Gynecology 94 (3) : 431-434. ScholarBank@NUS Repository. https://doi.org/10.1016/S0029-7844(99)00272-0|
|Abstract:||Objective: To determine the optimal interval for evacuation after preabortion cervical priming with vaginal misoprostol. Methods: One hundred eighty healthy nulliparas requesting legal termination of pregnancy between 6 and 11 weeks' gestation were assigned randomly to receive 400, 600, or 800 μg of intravaginal misoprostol. Vacuum aspiration was done after 3 hours in the 400-μg group and after 2 hours in the 600- and 800-μg groups. The degree of cervical dilatation before operation was measured with a Hegar dilator. Preoperative and intraoperative blood loss and associated side effects were also assessed. Results: Eleven (18.3%) and 15 (25.0%) women in the 600- and 800-μg groups, respectively, had cervical dilatation of at least 8 mm after an interval of 2 hours; 55 (91.7%) women who received 400 μg for a 3-hour interval had similar cervical dilatation. Using 400 μg as a baseline, the odds ratio (OR) was 0.02; 95% confidence interval (CI) was 0.01, 0.06 for 600 μg and OR 0.03; 95% CI 0.01, 0.09 for 800 μg for achieving successful preabortion cervical dilatation of at least 8 mm. The mean cervical dilatation of 6.7 mm and 6.8 mm for the higher doses was also significantly less than that of 8.1 for the 400-μg dose (P < .001). The mean preoperative and intraoperative blood loss was only statistically different when the 400- and 800-μg groups were compared (P = .03). There were also significantly more side effects, namely abdominal pain and fever above 38.0C, in the 600- and 800-μg groups (P < .001), compared with the 400-μg group. When the 600- and 800-μg groups were compared, there were still significantly more women complaining of abdominal pain (P < .001). None of the women in the study required analgesics for pain or antipyretics for fever. Conclusion: The minimal evacuation interval should be at least 3 hours for successful preabortion cervical priming. Copyright (C) 1999 The American College of Obstetricians and Gynecologists.|
|Source Title:||Obstetrics and Gynecology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 11, 2018
WEB OF SCIENCETM
checked on Jul 16, 2018
checked on Aug 3, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.