Please use this identifier to cite or link to this item: https://doi.org/10.1016/0090-6980(82)90053-3
Title: Termination of second trimester pregnancy with laminaria and intramuscular 16 phenoxy ω 17,18,19,20 tetranor PGE2methylsulfonylamine (sulprostone). A randomised study
Authors: Karim, S.M.M.
Ratnam, S.S. 
Lim, A.L.
Issue Date: 1982
Source: Karim, S.M.M.,Ratnam, S.S.,Lim, A.L. (1982). Termination of second trimester pregnancy with laminaria and intramuscular 16 phenoxy ω 17,18,19,20 tetranor PGE2methylsulfonylamine (sulprostone). A randomised study. Prostaglandins 23 (2) : 257-263. ScholarBank@NUS Repository. https://doi.org/10.1016/0090-6980(82)90053-3
Abstract: 16 phenoxy-ω-17,18,19,20 tetranor PGE2 methylsulfonylamide (Sul-prostone) was used for termination of second trimester pregnancy in four groups of 30 patients. The drug was administered in intramuscular doses of either 0.5 mg four hourly or 1.0 mg 8 hourly. In two groups of 30 patients a medium size sterile laminaria was inserted into the cervical canal eight hours before the start of prostaglandin treatment. In the group treated with 1.0 mg sulprostone eight hourly, 96.7% of those with laminaria and 86.7% without laminaria aborted in respective mean times of 11.2 hrs and 17.5 hrs. All 300 patients (100%) in the laminaria group treated with 0.5 mg sulprostone four hourly aborted within 30 hours in a mean time of 10.4 hours compared with 26 patients (86.7%) in a mean time of 16.7 hours in the group without laminaria. One patient receiving 0.5 mg sulprostone four hourly (no laminaria) sustained a cervical tear requiring repair. The incidence of nausea, vomiting, diarrhoea, cold and shivering was low and similar in the four groups.
Source Title: Prostaglandins
URI: http://scholarbank.nus.edu.sg/handle/10635/37161
ISSN: 00906980
DOI: 10.1016/0090-6980(82)90053-3
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