Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-3782(98)00014-0
Title: Lactate, lactate/pyruvate ratio and catecholamine interrelations in cord blood at delivery in complicated pregnancies
Authors: Nordstrom, L. 
Chua, S.
Roy, A. 
Arulkumaran, S. 
Naka, K.
Persson, B.
Keywords: Catecholamines
Fetal hypoxia
Lactate
Pyruvate
Issue Date: 1998
Source: Nordstrom, L., Chua, S., Roy, A., Arulkumaran, S., Naka, K., Persson, B. (1998). Lactate, lactate/pyruvate ratio and catecholamine interrelations in cord blood at delivery in complicated pregnancies. Early Human Development 52 (1) : 87-94. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-3782(98)00014-0
Abstract: The interrelationships between lactate, lactate/pyruvate (L/P) ratio and catecholamines (CA) in cord artery and vein blood were studied in 56 pregnancies who had complications in the antenatal period or during labour. This group of babies had higher CA levels and were more acidaemic than fetuses after normal pregnancies and labour. There were stronger correlations between lactate and noradrenaline (NA) (R = 0.56, P < 0.001), adrenaline (A) (R = 0.41, P = 0.002) and dopamine (DA) (R = 0.42, P = 0.001) in cord artery blood, than previously reported for normal deliveries. Correlations between L/P ratio and CAs were also significant, although weaker. Multiple regression analysis, using cord artery lactate as the dependent variable, revealed significant correlations for pH (P = 0.01) and pyruvate (P < 0.001), but not for the CAs. The subgroups with high lactate (> 75th centile) had significantly higher NA (P = 0.007) and DA (P < 0.001) in cord artery and NA (P < 0.001) and A (P < 0.001) in cord vein blood, as compared with the subgroup who had lower lactate concentrations. We conclude that fetal hypoxia induces fetal CA production as well as anaerobic metabolism with lactate production. However, the adrenergic stimulation seems not to contribute significantly to the fetal lactate production.
Source Title: Early Human Development
URI: http://scholarbank.nus.edu.sg/handle/10635/36946
ISSN: 03783782
DOI: 10.1016/S0378-3782(98)00014-0
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

14
checked on Dec 11, 2017

WEB OF SCIENCETM
Citations

9
checked on Dec 11, 2017

Page view(s)

94
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.