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Title: Elevated peritoneal fluid luteinizing hormone and prolactin concentrations in infertile women with endometriosis
Authors: Chew, P.C.T.
Peh, K.L.
Loganath, A. 
Gunasegaram, R.
Ratnam, S.S. 
Keywords: Endometriosis-associated infertility
Hormonal imbalance
Neuroendocrine disorder
Peritoneal fluid protein hormones
Issue Date: 1990
Citation: Chew, P.C.T., Peh, K.L., Loganath, A., Gunasegaram, R., Ratnam, S.S. (1990). Elevated peritoneal fluid luteinizing hormone and prolactin concentrations in infertile women with endometriosis. International Journal of Gynecology and Obstetrics 33 (1) : 35-39. ScholarBank@NUS Repository.
Abstract: In this study, we compared (Mann-Whitney U-test) the peritoneal fluid FSH, LH and PRL levels, measured by RIA, at the follicular and luteal phases of the menstrual cycle in women with (n = 43; age 25-44 years) and with no evidence of endometriosis (n = 35; age 25-39 years) who were considered as controls. Both follicular and luteal phase FSH concentrations of women with endometriosis were not statistically different (n = 22 vs 18; 0.32-5.8 vs 0.50-8.2 IU/l, P = 0.247; n = 13 vs 14; 0.6-6.5 vs 0.66-6.7 IU/l, P = 0.604) compared to their respective controls. In contrast to FSH, the concentrations of LH at follicular (n = 19 vs 17; 3.1-34.2 vs 2.3-12.2 IU/l, P = 0.01) and luteal (n = 17 vs 15; 2.1-95.4 vs 1.3-17.9 IU/l, P = 0.02) phases of the test group was significantly elevated at both phases of the cycle. With respect to differences in PRL concentrations at follicular phase no significant change (n = 21 vs 16; 1030-5800 vs 1305-4650 mIU/l; P = 0.255) was observed. The greatest difference in luteal PRL concentrations (P = 0.007) was obtained between the women with endometriosis and controls (n = 17 vs 17; 1895-8600 vs 1041-5000 mIU/l). The results suggest that disordered synchronization of neuroendocrine mechanisms controlling LH and PRL may be the underlying abnormality causing infertility in our group of patients with endometriosis.
Source Title: International Journal of Gynecology and Obstetrics
ISSN: 00207292
DOI: 10.1016/0020-7292(90)90652-2
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