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Title: Assessment of Osteogenesis and Cytotoxicity of Implants with hESC Progenies
Keywords: hESC progenies, osteogenesis, cytotoxicity, implants, cellular model
Issue Date: 22-Aug-2012
Citation: WONG KEE HAU (2012-08-22). Assessment of Osteogenesis and Cytotoxicity of Implants with hESC Progenies. ScholarBank@NUS Repository.
Abstract: Research and development for an ideal dental implant surface for bone growth has taken place for many years. Results from in vitro studies require further tests using animal models as an essential step prior to human clinical trial tests. However, no animal species fulfill the requirements of an ideal model to mimic human cells. Due to the limitations of animal studies, we embark on a pilot study using human embryonic stem cell (hESC) progenies to assess the cytotoxicity and osteogenesis of various dental implant surfaces. The objective is to study the possibility of a new cellular model to extrapolate in vitro implant material test results to human trials without going through animal testing. This study used hESC progenies to compare commercial implant materials and new surface modified implant materials to evaluate cytotoxicity and osteogenesis of the implant surfaces.
Appears in Collections:Master's Theses (Open)

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