Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/36536
Title: Assessment of Osteogenesis and Cytotoxicity of Implants with hESC Progenies
Authors: WONG KEE HAU
Keywords: hESC progenies, osteogenesis, cytotoxicity, implants, cellular model
Issue Date: 22-Aug-2012
Source: WONG KEE HAU (2012-08-22). Assessment of Osteogenesis and Cytotoxicity of Implants with hESC Progenies. ScholarBank@NUS Repository.
Abstract: Research and development for an ideal dental implant surface for bone growth has taken place for many years. Results from in vitro studies require further tests using animal models as an essential step prior to human clinical trial tests. However, no animal species fulfill the requirements of an ideal model to mimic human cells. Due to the limitations of animal studies, we embark on a pilot study using human embryonic stem cell (hESC) progenies to assess the cytotoxicity and osteogenesis of various dental implant surfaces. The objective is to study the possibility of a new cellular model to extrapolate in vitro implant material test results to human trials without going through animal testing. This study used hESC progenies to compare commercial implant materials and new surface modified implant materials to evaluate cytotoxicity and osteogenesis of the implant surfaces.
URI: http://scholarbank.nus.edu.sg/handle/10635/36536
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
WongKH Thesis 2013 feb.pdf3.83 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

182
checked on Dec 18, 2017

Download(s)

158
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.