Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/36366
Title: New Methods to Study Proline-Rich Disordered Regions and Their Structural Ensembles in Protein Signaling Pathways
Authors: LIU CHENGCHENG
Keywords: proline-rich, disordered proteins, structural ensemble, proline/serine-rich, kinase specificity, signaling pathways
Issue Date: 24-Aug-2012
Source: LIU CHENGCHENG (2012-08-24). New Methods to Study Proline-Rich Disordered Regions and Their Structural Ensembles in Protein Signaling Pathways. ScholarBank@NUS Repository.
Abstract: New methods are presented to study protein with proline-rich disordered regions in phosphorylation dependent pathways. A protein conformational sampling approach was combined with simple planes to examine spatial constraints imposed by membrane or nearby molecular assemblies to explain the near-membrane activation of the WNT pathway. A sensitive ?PSR? score was derived to detect Proline/Serine-rich disordered regions that play significant roles in signal transduction. A detailed statistical analysis exploring the interpositional dependence within phosphorylation sites showed minimal sequence dependency exists. A stepwise model for the evolution of disordered phosphorylation sites and signaling was deduced from the results of this study.
URI: http://scholarbank.nus.edu.sg/handle/10635/36366
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
LiuC.pdf3.19 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

246
checked on Dec 11, 2017

Download(s)

321
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.