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https://scholarbank.nus.edu.sg/handle/10635/36363
DC Field | Value | |
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dc.title | The Expression of CD44s in Squamous cell carcinoma of the oral tongue and association with clinicopathological factors and survival outcomes | |
dc.contributor.author | TAN KIAK MIEN, VERONIQUE | |
dc.date.accessioned | 2013-02-28T18:02:01Z | |
dc.date.available | 2013-02-28T18:02:01Z | |
dc.date.issued | 2012-08-23 | |
dc.identifier.citation | TAN KIAK MIEN, VERONIQUE (2012-08-23). The Expression of CD44s in Squamous cell carcinoma of the oral tongue and association with clinicopathological factors and survival outcomes. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/36363 | |
dc.description.abstract | Background CD44 is a potential marker to cancer stem-like cells in head and neck squamous cell carcinoma (SCC). We investigate the expression of CD44s in oral tongue SCC and correlate it with histopathological features and patient outcomes. Methods Immunohistochemical staining for CD44s was performed on 51 consecutive oral tongue SCC specimens. CD44s expression was categorised by staining intensity. The association of CD44s expression with adverse histopathological parameters and clinical outcomes were analysed. Results Patients with high CD44s staining intensity had better overall survival (HR 0.32, Log rank p = 0.04). Strong CD44s staining was also associated with better locoregional recurrence-free interval (HR 0.22, 95% CI 0.05 ? 0.87; p = 0.029). There was no association between CD44s expression and any of the adverse histopathological features studied. Conclusion Strong staining intensity of CD44s is an independent prognostic factor for better overall and locoregional recurrence-free survival in oral tongue SCC. | |
dc.language.iso | en | |
dc.subject | Oral tongue SCC, CD44s, Cancer stem cells | |
dc.type | Thesis | |
dc.contributor.department | OTOLARYNGOLOGY | |
dc.contributor.supervisor | LOH KWOK SENG | |
dc.contributor.supervisor | GOPAL IYER | |
dc.description.degree | Master's | |
dc.description.degreeconferred | MASTER OF SCIENCE | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Master's Theses (Open) |
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MSc thesis 130114.pdf | 1.15 MB | Adobe PDF | OPEN | None | View/Download |
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