Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/36363
Title: The Expression of CD44s in Squamous cell carcinoma of the oral tongue and association with clinicopathological factors and survival outcomes
Authors: TAN KIAK MIEN, VERONIQUE
Keywords: Oral tongue SCC, CD44s, Cancer stem cells
Issue Date: 23-Aug-2012
Source: TAN KIAK MIEN, VERONIQUE (2012-08-23). The Expression of CD44s in Squamous cell carcinoma of the oral tongue and association with clinicopathological factors and survival outcomes. ScholarBank@NUS Repository.
Abstract: Background CD44 is a potential marker to cancer stem-like cells in head and neck squamous cell carcinoma (SCC). We investigate the expression of CD44s in oral tongue SCC and correlate it with histopathological features and patient outcomes. Methods Immunohistochemical staining for CD44s was performed on 51 consecutive oral tongue SCC specimens. CD44s expression was categorised by staining intensity. The association of CD44s expression with adverse histopathological parameters and clinical outcomes were analysed. Results Patients with high CD44s staining intensity had better overall survival (HR 0.32, Log rank p = 0.04). Strong CD44s staining was also associated with better locoregional recurrence-free interval (HR 0.22, 95% CI 0.05 ? 0.87; p = 0.029). There was no association between CD44s expression and any of the adverse histopathological features studied. Conclusion Strong staining intensity of CD44s is an independent prognostic factor for better overall and locoregional recurrence-free survival in oral tongue SCC.
URI: http://scholarbank.nus.edu.sg/handle/10635/36363
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