Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/36223
Title: DECIPHERING THE SIGNALING NETWORKS UNDERLYING SIMVASTATIN-INDUCED APOPTOSIS IN HUMAN CANCER CELLS
Authors: ZHU YAN
Keywords: Simvastatin, cancer, apoptosis, Rho, ROS
Issue Date: 6-Aug-2012
Source: ZHU YAN (2012-08-06). DECIPHERING THE SIGNALING NETWORKS UNDERLYING SIMVASTATIN-INDUCED APOPTOSIS IN HUMAN CANCER CELLS. ScholarBank@NUS Repository.
Abstract: Statins are widely used as cholesterol-lowering drugs that selectively inhibit the enzyme HMG-CoA reductase and block cholesterol biosynthesis. Recent studies show that statins induce apoptotic cell death in several types of cancer cells. However, the underlying molecular mechanisms are still unclear. In this study, we showed that simvastatin activated the mitochondrial death pathway and inhibited colony-forming ability of HCT116 colorectal cancer cells. Exogenously added mevalonate or geranylgeranylpyrophosphate (GGPP), but not farnesylpyrophosphate (FPP), in combination with simvastatin prevented the growth-inhibitory effect of simvastatin. These data suggest that simvastatin exerts effects via inhibition of the mevalonate pathway and by modulating the functions of its downstream geranylgeranylated proteins, such as Rho GTPases. We then explored the signaling cascade downstream of inhibition of protein geranylgeranylation in simvastatin-treated HCT116 colorectal cancer cells.
URI: http://scholarbank.nus.edu.sg/handle/10635/36223
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ZhuYan.pdf6.33 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

151
checked on Dec 2, 2017

Download(s)

25
checked on Dec 2, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.