Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/36165
Title: UNDERSTANDING THE SPATIO-TEMPORAL DYNAMICS OF GUIDANCE SIGNALING DURING BORDER CELL MIGRATION IN DROSOPHILA
Authors: RISHITA S CHANGEDE
Keywords: Behavior of migrating cells, guidance signaling, Live Biosensor, border cell
Issue Date: 22-Aug-2012
Source: RISHITA S CHANGEDE (2012-08-22). UNDERSTANDING THE SPATIO-TEMPORAL DYNAMICS OF GUIDANCE SIGNALING DURING BORDER CELL MIGRATION IN DROSOPHILA. ScholarBank@NUS Repository.
Abstract: During Drosophila oogenesis, a group of cells delaminate from the epithelium and migrate towards the oocyte through the developing germline. This migration is guided by receptor tyrosine kinases (RTKs) PVR and DER, which respond to ligands secreted by the oocyte. The migration of the border cell was characterized and it was found that both the guidance receptors bring about different cellular behaviors in the migrating border cell clusters. To further study the guidance signaling, a biosensor probe was developed to visualize it. This probe detected the guidance signaling downstream of both the RTKs in space and time. This signal is dynamic in space over time. It is preferentially localized within the leading cell of the cluster and within the cluster as a whole, with a high preferential bias in the direction of migration. This localization is dependent on the both RTK and the ligand gradient.
URI: http://scholarbank.nus.edu.sg/handle/10635/36165
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