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Title: Ferrimagnetic MgFe2O4 nanoparticles for intra-arterial hyperthermia agent applications
Keywords: Ferrimagnetic, nanoparticle, MgFe2O4, hyperthermia, liver, cancer,
Issue Date: 21-Sep-2012
Citation: LEE SANGHOON (2012-09-21). Ferrimagnetic MgFe2O4 nanoparticles for intra-arterial hyperthermia agent applications. ScholarBank@NUS Repository.
Abstract: Ferrimagnetic Fe3O4 nanoparticles as a hyperthermia agent for liver cancer have been limited by the large size and low specific loss power (SLP). Accordingly, a new ferrimagnetic nanoparticle agent with smaller size, narrower size distribution and higher SLP, is required for intra-arterial hyperthermia modality. In this work, ferrimagnetic MFe2O4 (Ni, Mg, Co) nanoparticles were synthesized to investigate and compare the feasibility for a hyperthermia agent. Particularly, MgFe2O4 nanoparticles (Mg-NPs) with fast frequency response and high biocompatibility were chemically and mechanically modified during sol-gel synthesis process for intra-arterial hyperthermia agent applications. The modified Mg-NPs had a smaller size, a narrower size distribution and a higher SLP in the biologically tolerable range of AC magnetic field. In addition, the coated Mg-NPs mixed well with lipiodol exhibited high enough AC heating characteristics enabling them to be a suitable agent for the clinical use of liver cancer treatment in intra-arterial hyperthermia modality.
Appears in Collections:Master's Theses (Open)

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