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Title: Therapeutic effect of Hydrogen sulfide in a Parkinson's disease model
Authors: XIE LI
Keywords: Hydrogen sulfide, Parkinson's disease, oxidative stress, 6-OHDA
Issue Date: 6-Jun-2012
Citation: XIE LI (2012-06-06). Therapeutic effect of Hydrogen sulfide in a Parkinson's disease model. ScholarBank@NUS Repository.
Abstract: Parkinson?s disease (PD), characterized by loss of dopaminergic neurons in the substantia nigra, is a neurodegenerative disorder of the central nervous system. The present study was designed to investigate the effect of ACS84, an H2S-releasing L-Dopa derivate, in a 6-hydroxydopamine (6-OHDA)-induced PD model. ACS84 protected SH-SY5Y cells against 6-OHDA-induced cell injury and oxidative stress. The protective effect resulted from the stimulation of Nrf-2 nuclear translocation and the promotion of anti-oxidant enzymes expression. In the 6-OHDA-induced PD model, intragastric administration of ACS84 relieved the movement dysfunction of the model rats. Immunohistochemistry and HPLC analysis showed that ACS84 reversed the loss of tyrosine-hydroxylase positive (TH+) neurons in the substantia nigra and striatum, and the decline of dopamine concentration in the injured striatums of the 6-OHDA-induced PD model. Moreover, ACS84 reversed the elevated malondialdehyde level in model animals. In conclusion, ACS84 may prevent neurodegeneration via the anti-oxidative mechanisms and has potential therapeutic values for Parkinson?s disease.
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