Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/35744
Title: CHEMICAL CHARACTERIZATION OF GINSENOSIDES AND THEIR ASSOCIATED BIOACTIVITIES IN MURINE FIBROBLAST 3T3-L1 CELLS
Authors: YEO CHIA ROU
Keywords: Ginseng, protopanaxadiol, saponin, polyacetylene, adipocyte, adipogenesis
Issue Date: 24-Aug-2012
Source: YEO CHIA ROU (2012-08-24). CHEMICAL CHARACTERIZATION OF GINSENOSIDES AND THEIR ASSOCIATED BIOACTIVITIES IN MURINE FIBROBLAST 3T3-L1 CELLS. ScholarBank@NUS Repository.
Abstract: Ginsenosides are a group of dammarane triterpenoids commonly regarded as the bioactive compounds behind the pharmacological actions of ginseng. They can be further classified into two main groups, namely protopanaxadiols (PD) and protopanaxatriols (PT) type, depending on the backbone structure and sites of attachment. A handful of studies have shown that ginsenosides are capable of modulating adipocyte regulation and adipocytes are now recognized as a metabolically active organ that secretes a complex set of cytokines that contribute to the maintenance of health or to the development of disease. In this project, a simple and effective method for separation, purification and characterization of PD and PT type ginsenosides was developed. While crude Panax ginseng extract was found to possess insulin-sensitizing effects on adipocytes, PD type was found to be more potent in stimulating lipolysis, insulin regulation, and glucose uptake in 3T3-L1 cells, with 50 key adipogenic genes significantly up-regulated upon treatment.
URI: http://scholarbank.nus.edu.sg/handle/10635/35744
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