Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/35576
Title: ASYMMETRIC ORGANOCATALYTIC HENRY REACTION OF β–SUBSTITUTED α-KETO ESTERS VIA DYNAMIC KINETIC RESOLUTION
Authors: LIU GUANNAN
Keywords: asymmetric,organocatalytic,henry reaction,nitroaldol reaction,DKR,α-ketoester
Issue Date: 3-Aug-2012
Source: LIU GUANNAN (2012-08-03). ASYMMETRIC ORGANOCATALYTIC HENRY REACTION OF β–SUBSTITUTED α-KETO ESTERS VIA DYNAMIC KINETIC RESOLUTION. ScholarBank@NUS Repository.
Abstract: This thesis describes the development of diastereo- and enantioselective Henry reaction of ß-substituted a-keto esters using cinchona alkaloid derived bifunctional catalyst via dynamic kinetic resolution. Chapter 1 presents a brief historical background and development of asymmetric catalysis. Particularly, the asymmetric organocatalysis is introduced in detail. Then the historical background and development of dynamic kinetic resolution are summarized, especially, those organocatalytic methods are introduced in detail. In Chapter 2, the diastereo- and enantioselective Henry reactions of ß-substituted a-keto esters via dynamic kinetic resolution are investigated by using cinchona alkaloid derived bifunctional catalysts. Our approach combines organocatalytic Henry reaction and concept of dynamic kinetic resolution, and it also provides an access to biologically important and medicinal useful pyrrolidine derivatives.
URI: http://scholarbank.nus.edu.sg/handle/10635/35576
Appears in Collections:Master's Theses (Open)

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