Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/35242
Title: ANTI-CANCER EFFECTS OF THYMOQUINONE IN BREAST CANCER CELLS: INVOLVEMENT OF NON-HOMOLOGOUS END-JOINING AND TELOMERE-TELOMERASE HOMEOSTASIS
Authors: LIM SHI NI
Keywords: Anti-cancer, Breast cancer, Thymoquinone, DNA damage, Telomere dynamics
Issue Date: 11-Jul-2012
Source: LIM SHI NI (2012-07-11). ANTI-CANCER EFFECTS OF THYMOQUINONE IN BREAST CANCER CELLS: INVOLVEMENT OF NON-HOMOLOGOUS END-JOINING AND TELOMERE-TELOMERASE HOMEOSTASIS. ScholarBank@NUS Repository.
Abstract: Recent trends in cancer management have sparked a growing interest on discovering novel natural compounds that aim to effectively target cancer cells with minimal toxicity in normal cells. The anti-neoplastic effects of thymoquinone (TQ), a main active constituent of Nigella Sativa seeds, have been demonstrated, but the underlying mechanism remains to be elucidated. Recently, we showed TQ induces telomere shortening, DNA damage and apoptosis in glioblastoma cells. Here, the anti-cancer potential of TQ in breast cancer cells, MDA-MB-231 and MCF-7, is investigated. Reduced proliferative capacity was observed only in breast cancer cells, which showed inefficient repair of TQ-induced DNA damage in comparison to normal cells. These observations were associated with telomere dysfunction in breast cancer cells. Furthermore, genes and proteins involved in cell proliferation and DNA repair pathways were deregulated in TQ-treated cancer cells. Overall, our findings suggest the future possibility of translating this nature endowed compound for cancer treatment.
URI: http://scholarbank.nus.edu.sg/handle/10635/35242
Appears in Collections:Master's Theses (Open)

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