Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/35240
Title: EXPRESSION AND SECRETION OF HUMAN VISFATIN, AND ITS CORRELATION WITH METABOLIC PARAMETERS IN OBESE CHILDREN
Authors: OOI SHU QIN
Keywords: Adipokine, obesity, visfatin, SNP
Issue Date: 20-Jan-2012
Source: OOI SHU QIN (2012-01-20). EXPRESSION AND SECRETION OF HUMAN VISFATIN, AND ITS CORRELATION WITH METABOLIC PARAMETERS IN OBESE CHILDREN. ScholarBank@NUS Repository.
Abstract: The visfatin gene was screened in 24 Singaporean obese children. Four single nucleotide polymorphisms (SNPs) were detected in the upstream promoter and coding regions of the visfatin gene, and were genotyped in a cohort of 243 Singaporean obese children through direct DNA sequencing. The detected SNPs were shown to be statistically significantly associated with fasting serum visfatin, and with components of the metabolic syndrome including serum triglyceride, fasting glucose and frequency of hypertension. Furthermore, the diplotypes derived from the combination of genotypes of the detected SNPs were found to be significantly associated with these metabolic parameters. The interaction between the variant genotypes and physical activity level also had a significant effect on serum visfatin and metabolic risk factors including serum triglyceride, percentage of body fat and hypertension.
URI: http://scholarbank.nus.edu.sg/handle/10635/35240
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