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Title: The role of host cell ether lipids in influenza virus infection
Keywords: ether lipids, influenza virus, host cell, lipids
Issue Date: 6-Jun-2012
Citation: CHNG XUEMEI CHARMAINE (2012-06-06). The role of host cell ether lipids in influenza virus infection. ScholarBank@NUS Repository.
Abstract: A lipid profile of influenza virus-infected Chinese hamster ovary (CHO) cells was conducted using mass spectrometry, to provide an understanding of the importance of host cell lipids during an influenza virus infection. Interestingly, we noted an increase specifically in ether phosphatidylcholine (ePC) lipid species in influenza virus infected cells. Ether lipid-deficient CHO cells, NRel-4, were observed to impair influenza virus infection. With the use of siRNA knockdown technique, we further verified that human alveolar adenocarcinoma cells (A549) deficient in alkylglycerone phosphate synthase (AGPS), an enzyme catalyzing the second step of ether lipid biosynthesis, also produced a similar reduction in virus production. Based on this data and other published literature, we hypothesized that ether lipids could play important roles in the completion of influenza virus life cycle stages, especially at later stages of infection, including trafficking, assembly and budding.
Appears in Collections:Master's Theses (Open)

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